Newly released Pfizer documents show serious adverse events in animal studies

Pfizer released the first batch of their documents last night, which I am going through. One document that caught my eye was the Acuitas LNP+mRNA tissue distribution study in Wistar Han rats.

21 male & 21 female rats were dosed initially with 100ug mRNA but when all rats experienced adverse events the dose was dropped to 50ug. In the 100ug group, all rats experienced a 7% reduction in bodyweight. One of the 21 rats (5%) started declining with irregular respiration and after 30 hours was piloerect, hunched and hypersensitive to noise stimulus. The animal had to be humanely killed and the diagnostic necropsy showed a finding in the liver.

In the 50ug group of female rats, one animal had decreased activity, irregular respiration, and became hunched and piloerect in <48 hours.

https://phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf